AUTOIMMUNE1 60 capsules 500 milligrams

Panaxea AutoImmune 1

AutoImmune 1 is a versatile anti-inflammatory formula and important co-therapy in Th1 autoimmune conditions.

What AutoImmne 1 is Best For

AutoImmune 1 is recommended for people with autoimmunity and allergies caused by a damaged immune system.

AutoImmune 1 may be used for the following:

• Supports normal immune function
• Protection against autoimmunity
• Helps Inhibit IL-10 & 12 and interferon-gamma (IFN-y)
• Helps enhance IL-2 proliferation
• Helps enhance proliferation of lymphocytes and phagocytosis
• Helps regulate the function of T-lymphocyte and B-lymphocyte
• Helps regulate inflammatory response

How AutoImmune 1 Works

Autoimmunity and allergies are caused by a damaged immune system. Damage to the immune system typically represents a break in the continual development of immune cells in the lining of the intestines.

Autoimmune I reduces inflammation, tonifies adrenal (Kidney Qi) function, promotes IL 10, supports liver detoxification, supports normal lipid and glucose metabolism and addresses the complicated imbalances that occur not only in Th1 dominant autoimmune diseases but also in chronic illness.

AutoImmune 1 Serving Size

2 Capsules 2-3 times daily

AutomImmune 1 Ingredients

† Daily Value not established.

Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate

Key Ingredients

Sedum Sarmentosum (Chui Pen Cao)

Sedum sarmentosum Bunge Extract can enhance the proliferation of lymphocytes and the phagocytosis of the reticuloendothelial in mice with immunosuppression. and increase anti-oxidative functions of mice with acute hepatic damage.

Caution: none noted

Warning: none noted

Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts

Reference

1. Sun Weidong, Hu Haitao, Qian Shanqing, Dai Xiaojun Wang Dejun. Zhong Wai Yi Liao. 2008; 27(31): 19-21.

Tanshinone II-A

Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhiza

Pharmacological control of interleukin-12 (IL-12) and interferon-gamma (IFN-γ) production may be a key therapeutic strategy for modulating immunological diseases dominated by Th1-derived cytokine responses. Kang et al, (2000) investigated the effects of three different tanshinone pigments from Salvia miltiorrhiza (tanshinone I, dihydrotanshinone, and cryptotanshinone) on IL-12 production in mouse macrophages and on IFN-γ production in lymph node cells. All tested tanshinones significantly inhibited IL-12 production in lipopolysaccharide (LPS)-activated macrophages and also IFN-γ production in keyhole limpet hemocyanin (KLH)-primed lymph node cells in a dose-dependent manner. Dihydrotanshinone was more effective than tanshinone I or cryptotanshinone. Tanshinones significantly inhibited the expression of IL-12 p40 gene at the mRNA level.

Furthermore, tanshinones potently inhibited the promoter activation of IL-12 p40 gene and nuclear factor (NF)-kB binding to the kB site, suggesting that tanshinones may negatively regulate IL-12 production at the transcription level. These results may explain some known biological activities of tanshinones including their anti-inflammatory effect, and suggest a possible use of tanshinones in the treatment of immunological diseases dominated by Th1-derived cytokine responses.

References

Kang BY, Chung SW, Kim SH, et al. Immunopharmacology. Volume 49, Issue 3, September 2000, Pp 355-61. doi:10.1016/S0162-3109(00)00256-3

Portulaca oleracea (Ma Chi Xian)

In order to evaluate the effects of Portulaca oleracea polysaccharide (POP) on immune effects in Sarcoma180, the POP was obtained by water extraction and alcohol precipitation from Portulaca okeracea and was administered on the Sarcoma180 with 50 mg/kg, 100 mg/kg and 200 mg/kg respectively by intraperitoneal injection(IP) for 10 d. The inhibition rate of tumor growth, lymphocyte Proliferation phagocytic activity and IL-I IL-2 were investigated. The POP could significantly inhibit tumor growth; the inhibition rates of tumor growth were 16.92, 51.45 and 64.96 (%). Compared with NS group, the POP increased lymphocyte transformation capacity Phagocytic activity and the IL-1 and IL-2. secretion. The POP has obvious antineoplastic effect, and the main mechanism is to enhance the immune function of Sarcoma180.

References

Wang XiaoBo;Liu DianWu;Wang LiQin;Wang BenHua;Li XiaoRu;Xu LiQin. Tian Ran Chan Wu Yan Jiu Yu Kai Fa. 2005; 17(4): 453-456.

Caesalpinia Sappan (Su Mu)

The mechanism of the caesalpinia sappan L. is able to down regulate the function of T lymphocyte and B lymphocyte and inhibit the specific immune reaction induced by N2 acetylcholine receptor antigen (1).

Objective: To explore the regulation effect of haematoxylin on immunogenic reaction of rats suffered from UC by serum TLC subgroup, IgG and lysozyrne level examination. The adults Wistar rats were randomly divided into six groups, the models of UC (except the normal group) have been made by immune methods. Normal group and UC group were administered 0.9% NaC1 solution 2 mL(2 times a day). AELS groups were administered AELS solution 2 mL(2 times a day). All index were examined. Results The CD4^+ 8 + levels in haematoxylin treatment groups was significantly lower than that of models controls. The IgG levels in haematoxylin treatment groups was significantly lower than that of the models group. The level of LSZ was significantly lower than level of model group. There was not significant relationship between the treatment group and model group with thymus index and spleen index. The results show that hematoxilin can significantly improve the immune functions of rats suffered from UC (2).

References

1. LAI Cheng-hong, LI Zuo-xiao, JIA NG Ying-zheng, WU Yu-chuan. Zhong Guo Xian Dai Shen Jin Ji Bing Za Zhi. 205; 5(5): 330-333.

2. WANG Shu-min, LUO Yi-min. Nan Hua Da Xue Xue Bao: Yi Xue Ban: 2008; 36(4): 433-435.

Trichosanthin from Trichosanthes kirilowii (Tian Hua Fen)

Trichosanthin were put into the cells infected by HIV-1 and the activity of HIV P24 antigen and RT activity were detected. Results It was found that the cells added into trichosanthin showed RT activity negative, P24 Ag negative and no representative cell pathomorphology change while the cells added into distilled water showed RT activity positive, P24 Ag positive and representative cell pathomorphology changed, and the cells added into zidovudine showed RT activity negative, P24 Ag negative and no representative cell pathomorphology change. Conclusion Trichosanthin can inhibit human immunodeficiency virus 1 in vitro.

References

1. ZHAO Qiao-yun, LI Zhi-dong, Song Ji-rong. Xi Bei Da Xue Xue Bao: Zi Ran Ke Xue Ban. 2006; 36(1): 85-88.

Flavones from Cuscuta chinensis (Tu Si Zi)

Cuscuta seed could promote the growth of mice's immune organs such as spleen and thymus gland (P0.05) and improve the phagocytosis function of macrophagocyte (P0.05); also it could stimulate the cell multiplication of splenic lymphocyte and induce the production of interleukin. Conclusion: cuscuta seed could regulate and strengthen the mice's immune function.

Reference

1. Zhang Qinping, Shi Senlin. Zhe Jiang Lin Chuang Yi Xue. 2006; 8(6): 568-569.