Brand: Klaire Labs

Niacin-SR 100 tablets

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Product Description


Sustained-release niacin


Slow release of niacin over several hours helps avoid the uncomfortable flushing action of this B vitamin so that its full benefits on cholesterol metabolism can be obtained. Scored tablet.

Supplement Facts

Serving Size 1 Tablet
Amount Per Tablet% Daily Value
Niacin (as niacin)500 mg3,125%

Other Ingredients:

Vegetarian stearine, cellulose, silicon dioxide, magnesium stearate, and croscarmellose sodium.

Suggested Use

1 tablet daily with food or as directed by a healthcare professional.

Allergy Statement

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and corn. Contains no artificial colors, flavors, or preservatives.


If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product. Some forms of niacin may cause temporary flushing, tingling, itching, rash, or stomach upset. Consult your physician about periodic liver function testing if using this product long-term, or if you are taking more than 500 mg daily. KEEP OUT OF REACH OF CHILDREN.


What is Niacin-SR?

Niacin-SR supplies 500 mg of niacin (also known as nicotinic acid or vitamin B3), an essential B vitamin, in a sustained-release matrix that allows the niacin to be slowly released over a period of several hours. Niacin is a water-soluble nutrient, also known as vitamin B3 or nicotinic acid. Niacin-SR is provided in a scored tablet which allows for easier adjustment of intake if needed.

What does Niacin-SR do?

Through its metabolites, niacin is involved in over 200 biological processes including cholesterol and lipid synthesis, skin health, nervous and digestive system support, and the metabolism of carbohydrates, lipids, and proteins. Niacin, in high-potency amounts like Niacin-SR, is most notably involved in regulating cholesterol and lipoprotein metabolism.

How does Niacin-SR support normal cholesterol metabolism?

Niacin is readily absorbed in the stomach and small intestine where it is transported first to the liver and then to various tissues throughout the body. It is thought that niacin reduces the entry of free fatty acids into the liver thereby reducing the rate of very low-density lipoprotein (VLDL) cholesterol production. A decline in the liver's production of VLDL reduces the circulating levels of VLDL available for conversion to LDL cholesterol.

Why is Niacin-SR provided in a sustained-release form?

Niacin-SR allows the niacin to be released to the body at a slow rate rather than delivering the entire amount at once. Slow release helps maintain serum levels of niacin for a longer period of time. In addition, while high amounts of immediate-release forms of niacin often cause a reaction known as a "niacin flush" experienced as a temporary itching, tingling, or warming of the skin, Niacin-SR's sustained-release formulation helps minimize this reaction and improves compliance. The nicotinic acid form of niacin, as used in Niacin-SR, is the most effective form for supporting normal cholesterol and lipid metabolism. Other forms of niacin such as nicotinamide (also known as niacinamide) and inositol hexaniacinate contain little or no free nicotinic acid and have not demonstrated comparable efficacy.

How much Niacin-SR should I take?

Depending on the individual situation, 1 to 4 tablets providing 500 to 2,000 mg of niacin daily is usually sufficient. The amounts can be divided and taken several times per day or taken all at once. Higher doses are reserved for patients who are being specifically instructed and monitored by their healthcare professional.

Are there any side effects?

As mentioned before, a possible side effect of niacin supplementation is a "niacin flush." While Niacin-SR's sustained-release matrix helps to minimize this reaction, some individuals may still be sensitive even to the slow delivery system. This potential side effect is caused by a vasodilatation of cutaneous blood vessels which may produce a temporary tingling and warming sensation on the face, neck, arms, and chest. While the flushing sensation is not desirable, it is completely safe. This side effect usually disappears with continued use and may be reduced or eliminated when high doses of niacin are taken with a baby aspirin.

Use of high daily amounts of niacin, particularly in delayed-release forms, may also produce a temporary elevation in liver enzymes. Make sure your healthcare professional monitors your liver enzymes while taking this product and makes adjustments to your daily intake of niacin as he or she sees prudent.