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Sertain 60 veggie capsules 550 milligrams
Health Concerns Sertain 60 veggie capsules 550 milligrams
Sertain, 60 Tabs
Brand: Health Concerns
Unit Size: 60 vegetarian capsules, 550mg, 30 day supply
Dosage: 1 capsule BID, day between meals
Contraindications: Not for use with externally contracted pathogenic factors.
English name: Sertain Longevity/Longevitabs
Therapeutic Effects/Formula Benefits
Sertain is a proprietary formula rich in polymethoxyflavonoid (PMF) that has clinically proven cardiovascular and metabolic health-promoting benefits which prevents advanced glycation end products (AGEs), proteins or lipids that become glycated as a result of exposure to sugars. AGEs can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure, and Alzheimer's disease.
Sertain works through a mechanism of action similar to resveratrol's to enhance the SIRT1 gene pathway. The SIRT1 gene (Sirtuin 1) has a pivotal role in ameliorating insulin resistance and is considered a “longevity gene” since it influences numerous genes related to aging, early death, and the development of modern degenerative disorders such as heart disease, diabetes, cancer, and hypertension.i, ii
Sertain contains Health Concerns' black turmeric extract (BTE) derived from the rhizome of black turmeric of the species Kaempferia parviflora of the Zingiberaceae family. Health benefits of the herb include helping with metabolic syndrome, liver protection, promoting healthy blood glucose levels, and improving blood flow. In vitro studies show it reduces fat-cell differentiation as well as inhibits the production of advanced glycation end products (AGEs), which cause accelerated aging effects. iv, ii
In a study of BTE, body weight and abdominal fat accumulation were reduced in special mice that become obese. It was thought that the extract affected leptin levels and neurons directly or indirectly linked to suppressed food intake. In human subjects, the effect of BTE on body weight, blood pressure, glucose and lipid metabolism, AGEs production, and arterial stiffness was evaluated in a double-blind, placebo-controlled, crossover study. Twenty-seven healthy volunteers were orally given 100 mg of BTE, corresponding to 2 capsules a day of Sertain or a placebo for 7 weeks. Body weight declined significantly from 74.31.8 kg to 73.41.8 kg (p = 0.0033), and fasting blood glucose declined significantly from 106.36.5 mg/dL to 101.15.8 mg/dL (p = 0.0393) in the BTE group. Blood glucose dropped from 127.917.8 mg/dL to 120.714.9 mg/dL after ingestion, and improvement trends in the CAVI arterial stiffness index from 8.00.2 to 7.80.2 after ingestion were observed in the BTE group in those who had HbA1c values greater than 5.4%. The production of advanced glycation end products in the active group was reduced compared with the placebo group, which had a 6.72.2 ?g/ mL increase compared with only a 1.42.8 ?g/mL increase in the active group. No abnormal values were observed in body composition, blood chemistry, and blood pressure as adverse events during the test.
Sertain is also involved in the conjugation of bile acids (improves cardiovascular function), acts as a diuretic, and antianxiety nutrient.
Taurine L. Taurine,
Black Turmeric extract, Kaempferia parviflora
Maciocia, Giovanni. The Foundations of Chinese Medicine: A Comprehensive Text.Seattle, WA: Eastland Press, Inc. 2009. Print.
Bensky, D., Barolet, R. Formulas & Strategies Seattle, WA: Eastland Press, Inc 1990. Print
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.