Core Para-V Blend 2 ounce

Core Para-V Blend

Core Para-V Blend is a spagyrically prepared botanical extract containing extract of black walnut hull, wormwood aerial parts, sweet wormwood aerial parts, goldenseal rhiszome and clove bud.

Core Para-V Blend may support

• Beneficial microflora
• Intestinal epithelial integrity
• Intestinal environment inhospitable to parasitic worms
• Supports normal liver funciton
• Supports normal gastrointestinal function
• Supports cellular health
• Metabolic homeostasis

How does Core Para-V Blend Work?

Biological Response: The Gut-Liver Axis, A Critical Hub of Metabolism

Whereas the liver and colon function as digestive organs, they form a critical hub of carbohydrate, protein, and lipid metabolism known as the gut-liver axis. Conjoined by the hepatic portal vein and bile ductwork, the liver and large intestine, and more specifically its flora (microbiota), enjoy a symbiotic relationship in which immune and neuroendocrine signaling regulates the metabolism of assimilated nutrients and toxins.

The metabolic capacity of the liver relies heavily on the integrity of the intestinal mucosal barrier. Microbiota imbalance (dysbiosis) increases permeability of its epithelial layer (‘leaky gut’), allowing harmful substances to enter the portal circulation—triggering the release of proinflammatory cytokines. The microbiota functions as a clearinghouse by which raw materials produced within the gut-liver axis (fermented carbohydrates, bile acids) are converted to key molecular signals (such as short chain fatty acids) that sustain gut barrier health, hepatic detoxification, and cellular metabolism.

Phenols, terpenoids, and trace minerals found in black walnut, wormwood, sweet wormwood, goldenseal, and clove modulate signaling pathways that govern glucose and lipid metabolism. Bitter compounds such as sweet wormwood’s sesquiterpenes enhance nutrient absorption and promote elimination of metabolic waste via liver, bowel, and kidney. Assorted carotenoids, alkaloids, and flavonoids stimulate major hepatic detoxification pathways—including phase II conjugation and Nrf2 signaling.

Biological Response: Complementing Gut Mucosal Immunity Botanically

Through molecular signaling, the microbiota communicates with immune-related cells and molecules housed within the protective layers of the mucosal barrier—determining both magnitude and duration of the intestinal immune response. Mediated mainly by T cells, eosinophils, and the cytokines they produce, gut mucosal immunity relies on mast cells, macrophages, and a medley of secretions (histamine, mucins, short chain fatty acids) to create an environment hostile to parasite survival and conducive to worm expulsion.

Compounds found in Core Para-V Blend complement gut mucosal immunity both directly and indirectly. Naphthoquinones, sesquiterpenes, and alkaloids interact directly with parasite molecules and structures (nucleic acids, cytoskeleton, neural receptors), leading to worm mortality and elimination. Artemisinin, a sesquiterpene lactone found in sweet wormwood, contains an unusual peroxide ‘bridge’ that showers parasitic worms and their eggs with lethal free radicals when activated.

Various flavonoids, tannins, carotenoids, and minerals modulate intestinal immunity indirectly through improved metabolism and molecular signaling. As free radical scavengers, naphthoquinones, terpenoids, and phenolics provide gastrointestinal and hepatic protection; they also promote the natural production of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase.

Botanical Profile

Core Para-V Blend is sourced from Juglans nigra, Artemisia absinthium, Artemisia annua, Hydrastis canadensis, and Syzygium aromaticum. Whether a deciduous hardwood tree like black walnut (Juglans nigra) or a rhizomatous flowering perennial such as goldenseal (Hydrastis canadensis), these seemingly diverse plants are united phytochemically by their bitter compounds. Intensely bitter molecules such as thujone, a monoterpene in wormwood, berberine, an alkaloid in goldenseal, and eugenol, a phenolic in clove, synergize to support digestive health, hepatic detoxification, cellular metabolism, and gut mucosal immunity.

Spagyrically Prepared Botanicals

Core Para-V Blend is prepared using a unique handcrafted method known as spagyric processing. A branch of the medieval science known as alchemy and the forerunner of modern chemistry, spagyria is an herbal manufacturing method first described in the early 16th century by the Swiss physician Paracelsus in his book Liber Paragranum. The word comes from the ancient Greek ‘to draw out’ and ‘to gather.’ Its essential meaning is ‘to separate and join.’

Ingredients

Black Walnut Hull (Juglans nigra)

Wormwood Aerial Parts (Artemisia absinthium)

Sweet Wormwood Aerial Parts (Artemisia annua)

Goldenseal Rhizome (Hydrastis canadensis)

Clove Bud (Syzygium aromaticum)

Warning

If pregnant or breastfeeding, consult a healthcare professional before use.