Xymogen Calcium D-Glucarate
Calcium D-Glucarate supports normal blood and tissue levels of beta-glucuronidase activity by providing a form of glucaric acid.
What Calcium D-Glucarate is best for:
Calcium D-Glucarate may be used for the following:
- Supports Normal Blood and Tissue Levels of Beta-gluronidase
- Supports Detoxification of Estrogens, Androgens, ( Environmental Toxins (E.g.: polyamine hydrocarbons, nitrosamines), etc.
How Calcium D-Glucarate works:
Ingestion of supplemental Calcium D-Glucarate increases net glucuronidation and the subsequent elimination of certain mutagenic compounds. Glucuronidation, the most important of the Phase 2 detoxification pathways both quantitatively and qualitatively, is the pathway used by estrogens and androgens, some steroid hormones and lipid- soluble toxins such as polycyclic aromatic hydrocarbons, some nitrosamines, heterocyclic amines and aromatic amines. Glucuronide conjugates are eliminated via the urine or bile.
Beta-glucuronidase, an enzyme produced by intestinal flora, cleaves glucaronic acid from the glucuronide conjugate allowing the toxins freed up in this process to get reabsorbed by the ileal mucosa, reexposing the body for prolonged periods, thus increasing the potential for harm. Calcium D-glucarate indirectly inhibits betaglucuronidase activity in the intestine, thereby preventing deconjugation and reabsorption of toxins and increasing their elimination.
Calcium D-Glucurate does not inhibit betaglucuronidase directly. Taken orally it dissolves in the stomach and forms D-glucaric acid, from which is derived the potent beta-glucuronidase inhibitor, D-glucaro-1,4-lactone. Unfortunately, the body rapidly clears D-glucaro-1,4-lactone. However, oral Calcium D-Glucarate can be considered a sustained release form of the D-glucaro-1,4-lactone.
Although the mechanism of antioxidant action is as yet unknown, it is also worthy to note that the protective effects of D-glucaro-1,4- lactone against oxidative/nitrative modifi cations of plasma proteins have been demonstrated.
Keep out of reach of children.
Take only under supervision of a healthcare practitioner.