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Manufacturer: Life Extension SAMe (S-adenosyL-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways: - Methylation (contributing methyl groups to activate certain molecules)29,30
- The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)31-33
- Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)34-36
In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the co-factors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine.29,30,32,35-37* SAMe has multi-modal mechanisms of action that are used throughout the body, and especially the liver. In order to perform its detoxification role, the liver performs large numbers of complex enzymatic reactions continually.34,36 SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant, glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.29,34-36* Supplement Facts Serving Size 2 tablets | Servings Per Container 10 | Amount Per Serving | S-AdenosyL-Methionine | 400 mg | Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow ochre. | Contains soybeans. Contains yeast. This product contains NO milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, colors, flavors, or preservatives. |
Dosage and Use - Take two tablets two to three times daily in divided doses morning, midday, and late afternoon, or as recommended by a healthcare practitioner.
- Take with co-factors vitamins B12, B6, and folic acid.*
- Taking this product with food may avoid gastrointestinal disturbance.
- Refrigeration is recommended.
Caution SAMe should not be taken by those diagnosed with bipolar disorder. Warnings - Keep out of reach of children.
- Do not exceed recommended dose.
- Do not purchase if outer seal is broken or damaged.
- If you have a bad reaction to product discontinue use immediately.
- When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Related Keywords Depression, Inflammation, Arthritis
About Life Extension
Life Extension is a global authority on health, wellness and nutrition as well as a provider of scientific information on anti-aging therapies. They supply only the highest quality nutritional supplements, including minerals, herbs, hormones and vitamins.
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