Lipid Support Formula 60 veggie capsules

Manufacturer: Silk Road

Lipid Support Formula 60 Veggie Caps

Dosage: 2 Caps/day

Helps Support Healthy Cholesterol Levels

Amount Per Serving:
Delta Tocotrienol 100 mg
Ubiquinol (Kaneka QH™ active form of Coenzyme Q10) 100 mg

TOCOTRIENALS CHOLESTEROL LOWERING EFFECTS

Tocotrienols have been shown to reduce the level of LDL (the "bad" form of cholesterol) and apolipoprotein B, both of which are important risk factors for atherosclerosis and cardiovascular disease.

Tocotrienols and statin drugs such as lovastatin both lower cholesterol by suppressing the activity of the enzyme HMG-CoA reductase, although through different mechanisms. The statins are thought to affect the enzyme through competitive inhibition, while the tocotrienols accelerate enzyme degradation and decrease the efficiency of mRNA translation of the enzyme.[1] This difference in mechanism is believed to be a reason for the absence of adverse side effects with tocotrienols, contrary to the common side effects of the statin drugs.

Some studies have demonstrated a significant reduction of both total and LDL cholesterol with tocotrienols administered to patients with high serum lipids. In a double blind, crossover study on 25 patients with high cholesterol levels, the patients in the treatment group were given 4 capsules daily of 50 mg tocotrienols mixed with palm oil, while the control group received only corn oil. At the end of the 8-week trial period, total cholesterol and LDL cholesterol had decreased significantly (15% and 8%) in the 15 subjects given the palm tocotrienols. There was no change in the control group.[2]

Total cholesterol and LDL-cholesterol were reduced even more (17% and 24% respectively) when tocotrienols were added to a low fat, low cholesterol diet and alcohol-free regimen in another double-blind, longer-lasting trial (12 weeks).[3] Other important cardiovascular risk factors were reduced by tocotrienols. Apoli-poprotein B and lipoprotein(a), strong predictors of cardiovascular disease, as well as thromboxane B2 and platelet factor 4 were all significantly lowered in the tocotrienol-treated group (15%, 17%, 31% and 14% respectively).

Tocotrienols were studied in combination with the statin drug lovastatin in another study. The 28 patients with elevated cholesterol levels in this double blind, cross-over clinical trial were placed on the American Heart Association Step-1 diet before beginning the treatment. After 35 days on the diet, they were given low doses of lovastatin, tocotrienols and alpha-tocopherol (and combinations of these agents) in stages of 35 days each, while staying on the diet. The combination of lovastatin (10mg) and palm tocotrienols (50mg) had a lipid-lowering effect of 20-25%, while tocotrienols or lovastatin alone in the same dosages reduced LDL-cholesterol 18% and 15% respectively. No side effects were reported during the study. It is important to note that dosages of cholesterol-lowering drugs should not be reduced on the basis of this preliminary study.[4]

Coenzyme Q10 (CoQ10) Helps Maintain Normal Blood Pressure & Lipids

An extensive eight-year clinical trial found that CoQ10 helped patients with existing cardiovascular disease to improve their condition and decrease their reliance on heart medications. After 18 months of CoQ10 supplementation, an impressive 58% improved their American Heart Association scores by one "class," or health gradient, while 28% improved by two classes. Most importantly, nearly half of all participants demonstrated a decreased need for medications.[5]

A 12 week double-blind, placebo-controlled trial of 83 people with systolic hypertension examined the effect of CoQ10 supplements (60 mg twice daily). After the 12 weeks, there was a mean reduction in systolic blood pressure of 17.8 mm Hg in the Coq10-treated group.[6]

Another study conducted at the University of Western Australia looked at the effect of CoQ10 on blood pressure and glycemic control in 74 people with type 2 diabetes. [7] Participants were randomly assigned to receive either 100mg CoQ10 twice daily, 200mg of the drug fenfibrate, both, or neither for 12 weeks.

CoQ10 significantly reduced systolic and diastolic blood pressure(mean reduction 6.1 mm Hg and 2.9 mm Hg respectively). There was also a reduction in HbA1C, a marker for long-term glycemic control.

References:

1. Parker RA, et al. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 1993 May 25;268(15):11230-8.

2. Qureshi AA, et al. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). Am J Clin Nutr 1991 Apr;53(4 Suppl):1021S-1026S.

3. Qureshi A.A., et al. Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolomic humans. Journal of Nutritional Biochemistry ( J. NUTR. BIOCHEM. ) (United States) 1997, 8/5 (290-298).

4. Qureshi AA, et al. Synergistic effect of tocotrienol-rich fraction (TRF(25)) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans. J Nutr Biochem 2001 Jun;12(6):318-329.

5. Langsjoen H, Langsjoen P, Langsjoen P, Willis R, Folkers K. Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med. 1994;15 Suppls165-75.

6. Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind,placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7.

7. Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. "Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes." Eur J Clin Nutr. 56.11 (2002): 1137-1142.

Silk Road is the product line that is manufactured exclusively for our clinic, Acupuncture Atlanta. The products that you find in this line are used extensively in the clinic and have a high degree of efficacy.