Best Joint Support featuring ArthriBlend-SR 120 tablets

Manufacturer: Doctors Best

Best Joint Support featuring ArthriBlend-SR™ contains the connective tissue-supportive nutrient glucosamine sulfate, which provides essential building blocks for joint cartilage. Glucosamine sulfate has been studied in numerous trials for its ability to maintain and sustain healthy joint function. * The formula also contains two powerful herbal extracts, Boswellin® and Curcumin C3 Complex®. The joint protective and free radical scavenging properties of these nutrients provide a synergy that is complementary to glucosamine sulfate in progressively supporting enzymatic and metabolic processes that serve to promote optimal joint health and comfort. * Bioperine® is a patented extract from black pepper that has been used in conjunction with curcumin and other nutrients to enhance nutrient bioavailability and uptake.

Best Joint Support featuring ArthriBlend-SR™ features a uniquesustained release delivery system, ensuring optimal availability of the health-promoting herbal and nutritional ingredients to the body throughout the day and night.

Glucosamine sulfate

Glucosamine sulfate consists of glucosamine, an amino sugar extracted from "chitin," a component of shellfish skeletons. "Chitin," the resilient polysaccharide that forms the structural framework of animal shells, is a long-chain polymer consisting of many glucosamine molecules linked together.

Note: Glucosamine sulfate is derived from the shells of ocean-growing shellfish. It is processed to remove all residues of protein and impurities, yielding pure glucosamine sulfate as the final material.

Boswellin®

Boswellia serratais a large, branching, deciduous tree that grows abundantly in the dry, hilly parts of India . The gum resin exudate of Boswellia serrata has been used in the Ayurvedic herbal system for supporting joint function, respiratory health and liver function. Boswellin® is an extract of the purified compound obtained from the tree's gummy resin.

Research has shown that the major benefits ofBoswellia serrata in promoting healthy joints can be attributed to the active constituents of the plant known as boswellic acids. The most important of these compounds include beta-boswellic acid, acetyl-beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid. An analysis of samples of Boswellin®Boswellia serrata extract showed that the extract contains the major boswellic acids at high levels, with a total organic acid content of over 70%.

Curcumin C3 Complex is a standardized extract ofCurcuma longa root, commonly known as turmeric. Turmeric is a yellow spice used in curried dishes. In the Far East , turmeric is valued for more than just its culinary applications; turmeric is named in ancient Ayurvedic and Chinese herbal texts as a traditional folk remedy. Historically, turmeric was used externally for wounds and sprains, and internally to promote digestive wellness, joint health, liver function, and to support the immune system.

The active ingredients in turmeric are a group of plant substances called curcuminoids. Known collectively as "Curcumin," curcuminoids have demonstrated potent antioxidant properties in scientific studies. Curcuminoids benefit joints and other tissues by helping to neutralize free radicals. Curcuminoids are responsible for turmeric's distinctive yellow color. Although the term "Curcumin" is used as a name for curcuminoids, "pure" curcumin is just one curcuminoid.

Curcumin C3 Complex Ò supplies 95% total curcuminoids, including "pure" curcumin, bisdemethoxy curcumin and demethoxy curcumin.

Best Joint Supporting featuring ArthriBlend-SR 120T

Suitable for vegetarians

Best Joint Support featuring Arthriblend-SR™ contains connective tissue-supporting glucosamine sulfate, which provides essential building blocks for joint cartilage. Glucosamine has been extensively studied for its ability to sustain healthy joint function.* The formula also contains two powerful herbal extracts, Boswellin® and Curcumin C3 Complex®. Their joint protective and free radical scavenging properties work synergistically with glucosamine sulfate in progressively supporting enzymatic and metabolic processes that promote optimal joint health and comfort.*

Bioperine® is a patented black pepper extract that has been used in conjunction with curcumin and other nutrients to enhance nutrient bioavailability and uptake. Best Joint Support featuring Arthriblend-SR™ features a uniquesustained releasedelivery system, ensuring optimal availability of the health-promoting herbal and nutritional ingredients to the body throughout the day and night.

Arthriblend-SR® is a patent pending blend of Sabinsa Corp. ArthriBlend, Bioperine, Boswellin and Curcumin C3 Complex (U.S. Patent # 5,861,415) are registered trademarks of Sabinsa.

Suggested Use: Take 2 tablets every 12 hours. Take 4 tablets daily.

Supplement Facts

Serving Size: 2 tablets

Servings per container: 60 servings

Amount Per Serving %DV

Glucosamine Sulfate 750mg †

Boswellin 200mg †

(Boswellia Serrata Extract)

Curcumin C3 Complex 100mg †

(Curcuminoids from Curcuma longa (Turmeric) roots)

Bioperine 5mg †

(Black pepper fruit extract)

† Daily Value not established.

Other Ingredients: Microcrystalline cellulose, povidone, carbopol, magnesium stearate (vegetable source), sodium starch glycollate, hydroxypropyl methylcellulose.

Contains nothing other than listed ingredients.

120T

Benefits

Supports joint function and tissue health*

To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.

Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis.^1,2,3

Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued.³

Promotes optimal joint comfort, function and flexibility*

Boswellia serrata(Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects.⁴

Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesisin vitro, promoting a healthy balanced production of these components of the immune system.⁵ Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.⁶ Other trials lend further support to Boswellia's ability to promote healthy joint function.^4,6,7

Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.⁸

Curcumin demonstrates several otherin vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body's inflammatory response.⁹ Curcumin also demonstratesin vitroinhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.^9,10,11

Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.¹² Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.

Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.¹³ Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.¹⁴

Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. ¹⁵ These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.

Sustained Release - For lasting joint comfort and convenient dosing

To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.

Safety

Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.

Does Not Contain:milk, egg, wheat, corn, sugar, sweeteners, salt, or preservatives.